Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core-shell nanoparticles targeting the heterogeneous tumor cells of glioma

• Main Authors: He-Lin Xu (Author), Zi-Liang Fan (Author), De-Li ZhuGe (Author), Meng-Qi Tong (Author), Bi-Xin Shen (Author), Meng-Ting Lin (Author), Qun-Yan Zhu (Author), Bing-Hui Jin (Author), Yasin Sohawon (Author), Qing Yao (Author), Ying-Zheng Zhao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, combination drug therapy is one of the most effective approaches to glioma treatment. However, due to the inherent dissimilar pharmacokinetics of individual drugs and blood brain barriers, it was difficult for the concomitant drugs to simultaneously be delivered to glioma in an optimal do...