Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants

• Main Authors: Aarti Sawant‐Basak (Author), Arthur J. Bergman (Author), Jessica Mancuso (Author), Sakambari Tripathy (Author), James R. Gosset (Author), Laure Mendes da Costa (Author), William P. Esler (Author), Roberto A. Calle (Author)
• 格式: 圖書
• 出版: Wiley, 2024-02-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Co‐administration of clesacostat (acetyl‐CoA carboxylase inhibitor, PF‐05221304) and ervogastat (diacylglycerol O‐acyltransferase inhibitor, PF‐06865571) in laboratory models improved non‐alcoholic fatty liver disease (NAFLD)/non‐alcoholic steatohepatitis (NASH) end points and mitigated cle...