A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models.

• Main Authors: Aura R Garrison (Author), Charles J Shoemaker (Author), Joseph W Golden (Author), Collin J Fitzpatrick (Author), John J Suschak (Author), Michelle J Richards (Author), Catherine V Badger (Author), Carolyn M Six (Author), Jacqueline D Martin (Author), Drew Hannaman (Author), Marko Zivcec (Author), Eric Bergeron (Author), Jeffrey W Koehler (Author), Connie S Schmaljohn (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no licensed vaccines to prevent CCHFV-associated disease. We developed a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV...