Labetalol and soluble endoglin aggravate bile acid retention in mice with ethinylestradiol-induced cholestasis

• Main Authors: Ivone Cristina Igreja Sá (Author), Katarina Tripska (Author), Fatemeh Alaei Faradonbeh (Author), Milos Hroch (Author), Hana Lastuvkova (Author), Jolana Schreiberova (Author), Marian Kacerovsky (Author), Miguel Pericacho (Author), Petr Nachtigal (Author), Stanislav Micuda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Labetalol is used for the therapy of hypertension in preeclampsia. Preeclampsia is characterized by high soluble endoglin (sEng) concentration in plasma and coincides with intrahepatic cholestasis during pregnancy (ICP), which threatens the fetus with the toxicity of cumulating bile acids (BA). Ther...