Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

• मुख्य लेखकों: Elena N. Voropaeva (लेखक), Tatyana I. Pospelova (लेखक), Mikhail I. Voevoda (लेखक), Vladimir N. Maksimov (लेखक), Yuriy L. Orlov (लेखक), Olga B. Seregina (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2019-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background The knowledge about specific mechanisms generating TP53 dysfunction in diffuse large B-cell lymphoma is limited. The aim of the current study was to comprehensively explore TP53 gene variability resulting from somatic mutations, promoter methylation, and allelic imbalance in tumo...