Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

• Glavni autori: Donya Naz Divsalar (Autor), Conrad Veranso Simoben (Autor), Cole Schonhofer (Autor), Khumoekae Richard (Autor), Wolfgang Sippl (Autor), Fidele Ntie-Kang (Autor), Ian Tietjen (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental "shock-and-kill" therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected...