Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

• Main Authors: Donya Naz Divsalar (Author), Conrad Veranso Simoben (Author), Cole Schonhofer (Author), Khumoekae Richard (Author), Wolfgang Sippl (Author), Fidele Ntie-Kang (Author), Ian Tietjen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental "shock-and-kill" therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected...