Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption

• Main Authors: Sven de Mey (Author), Heng Jiang (Author), Cyril Corbet (Author), Hui Wang (Author), Inès Dufait (Author), Kalun Law (Author), Estelle Bastien (Author), Valeri Verovski (Author), Thierry Gevaert (Author), Olivier Feron (Author), Mark De Ridder (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic conditions, particularly for phenformin, is largely unknown. This study therefore examines whether metformin and phenfo...