Beneficial Effect of Candesartan on Rat Diastolic Heart Failure

• Main Authors: Ryotaro Wake (Author), Shokei Kim-Mitsuyama (Author), Yasukatsu Izumi (Author), Kaoru Yoshida (Author), Yasuhiro Izumiya (Author), Tokihito Yukimura (Author), Masayuki Shiota (Author), Minoru Yoshiyama (Author), Junichi Yoshikawa (Author), Hiroshi Iwao (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we examined whether an angiotensin II type 1 (AT1)-receptor blocker improves diastolic heart failure (DHF) in Dahl salt-sensitive (DS) rats. DHF was prepared by feeding DS rats on 8% NaCl diet from 7 weeks of age. DHF was estimated with echocardiography by measuring E velocity / A vel...