Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

• Egile Nagusiak: Yong Zhu (Egilea), Andrey A. Sysoev (Egilea), Paulo H. Jacob Silva (Egilea), Marine Batista (Egilea), Francesco Stellacci (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified β-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model even when administered 24 h post-in...