Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

• Main Authors: Yong Zhu (Author), Andrey A. Sysoev (Author), Paulo H. Jacob Silva (Author), Marine Batista (Author), Francesco Stellacci (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified β-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model even when administered 24 h post-in...