Influence of the ionic strength on the physicochemical properties of methotrexate-loaded chitosan polyelectrolyte complexes

• Main Authors: Sandra Barbosa Neder Agostini (Author), Victor Lima de Sousa Machado (Author), Luciano Sindra Virtuoso (Author), Denismar Alves Nogueira (Author), Gislaine Ribeiro Pereira (Author), Flávia Chiva Carvalho (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Polyelectrolyte complexes (PECs) as drug delivery systems are widely explored since they are easily obtained by coacervation and biopolymers can be associated. However, particle distribution is a challenging critical parameter that has been infrequently focused. This work evaluated the effe...