Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

• Main Authors: Samantha M. Ayoub (Author), Fabiana Piscitelli (Author), Cristoforo Silvestri (Author), Cheryl L. Limebeer (Author), Erin M. Rock (Author), Reem Smoum (Author), Mathew Farag (Author), Hannah de Almeida (Author), Megan T. Sullivan (Author), Sébastien Lacroix (Author), Besma Boubertakh (Author), Nayudu Nallabelli (Author), Aron H Lichtman (Author), Francesco Leri (Author), Raphael Mechoulam (Author), Vincenzo Di Marzo (Author), Linda A. Parker (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: The endocannabinoidome mediators, N-Oleoylglycine (OlGly) and N-Oleoylalanine (OlAla), have been shown to reduce acute naloxone-precipitated morphine withdrawal affective and somatic responses.Objectives: To determine the role and mechanism of action of OlGly and OlAla in withdrawal respo...