Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

• প্রধান লেখক: Samantha M. Ayoub (লেখক), Fabiana Piscitelli (লেখক), Cristoforo Silvestri (লেখক), Cheryl L. Limebeer (লেখক), Erin M. Rock (লেখক), Reem Smoum (লেখক), Mathew Farag (লেখক), Hannah de Almeida (লেখক), Megan T. Sullivan (লেখক), Sébastien Lacroix (লেখক), Besma Boubertakh (লেখক), Nayudu Nallabelli (লেখক), Aron H Lichtman (লেখক), Francesco Leri (লেখক), Raphael Mechoulam (লেখক), Vincenzo Di Marzo (লেখক), Linda A. Parker (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Rationale: The endocannabinoidome mediators, N-Oleoylglycine (OlGly) and N-Oleoylalanine (OlAla), have been shown to reduce acute naloxone-precipitated morphine withdrawal affective and somatic responses.Objectives: To determine the role and mechanism of action of OlGly and OlAla in withdrawal respo...