Patient‐derived pancreatic tumour organoid implantation establishes novel pre‐cachexia mouse models

• Main Authors: Merel R. Aberle (Author), Rianne D.W. Vaes (Author), Wouter R.P.H. van deWorp (Author), Ludwig J. Dubois (Author), Natasja G. Lieuwes (Author), Rianne Biemans (Author), Ramon C.J. Langen (Author), Frederik‐Jan vanSchooten (Author), Ronald M. vanDam (Author), Steven W.M. Olde Damink (Author), Sander S. Rensen (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The poor survival of pancreatic cancer patients is largely attributable to cachexia, a syndrome of severe weight and muscle loss. To investigate the aetiology of cancer cachexia, preclinical models that closely recapitulate the human disease process are essential. Patient derived...