Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

• Main Authors: Shuo Yang (Author), Bihui Cao (Author), Guangyu Zhou (Author), Lipeng Zhu (Author), Lu Wang (Author), Li Zhang (Author), Hang Fai Kwok (Author), Zhenfeng Zhang (Author), Qi Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells. An immune checkpoint molecule, B7-H3, plays an inhibitory role in modulation of NK ce...