Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein

• Main Authors: Zheng Yang (Author), James Loy (Author), Brian Poirson (Author), Yanshan Dai (Author), Surendran Rajendran (Author), Shihua Xu (Author), Vanessa Spires (Author), Murali Gururajan (Author), Zheng Lin (Author), Jaren Arbanas (Author), Stephen Carl (Author), Samantha Pace (Author), Yun Wang (Author), John Mehl (Author), Krishna Vasudevan (Author), Thomas Spires (Author), Ruslan Novosiadly (Author), Shodeinde Coker (Author), Raymond Perez (Author), Kelly Covello (Author), Paul Morin (Author), Robert Graziano (Author), Miranda Broz (Author), Lois Lehman-McKeeman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed to quantitatively integrate preclinical pharmacology and toxicology data for determining the therapeutic index (TI) of an interleukin-10 (IL-10) fragment crystallizable (Fc) fusion protein. Mouse Fc fused with mouse IL-10 (mFc-mIL-10) wa...