Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

• Main Authors: Rosario Diaz (Author), Sandra A Luengo-Arratta (Author), João D Seixas (Author), Emanuele Amata (Author), William Devine (Author), Carlos Cordon-Obras (Author), Domingo I Rojas-Barros (Author), Elena Jimenez (Author), Fatima Ortega (Author), Sabrinia Crouch (Author), Gonzalo Colmenarejo (Author), Jose Maria Fiandor (Author), Jose Julio Martin (Author), Manuela Berlanga (Author), Silvia Gonzalez (Author), Pilar Manzano (Author), Miguel Navarro (Author), Michael P Pollastri (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter...