Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

• Main Authors: Zhihui Ding (Author), Jing Zhao (Author), Xufang Wang (Author), Wei Li (Author), Chong Chen (Author), Chen Yong (Author), Yiye Zhu (Author), Fang Tian (Author), Li Liu (Author), Manshu Yu (Author), Enchao Zhou (Author), Liubao Gu (Author), Chunlei Yao (Author), Kun Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the treatment of some kidney diseases. In our previous s...