Cover Image

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the treatment of some kidney diseases. In our previous s...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhihui Ding (Author), Jing Zhao (Author), Xufang Wang (Author), Wei Li (Author), Chong Chen (Author), Chen Yong (Author), Yiye Zhu (Author), Fang Tian (Author), Li Liu (Author), Manshu Yu (Author), Enchao Zhou (Author), Liubao Gu (Author), Chunlei Yao (Author), Kun Gao (Author)
Format:	Book
Published:	Frontiers Media S.A., 2022-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
by: Yulong Li, et al.
Published: (2022)

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
by: Liang Yan, et al.
Published: (2021)

Myricetin activates the Caspase-3/GSDME pathway via ER stress induction of pyroptosis in lung cancer cells
by: Jicheng Han, et al.
Published: (2022)

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer
by: Fei Yu, et al.
Published: (2022)

Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity
by: Weijie Zhu, et al.
Published: (2024)

Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation
by: Wei Li, et al.
Published: (2019)

Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization
by: Jinsong Su, et al.
Published: (2022)

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis
by: Yueting Zhang, et al.
Published: (2022)

Analysis of a process of peroxidation, caspase-3 and caspase-8 in patients with autoimmune thyroiditis
by: M. I. Sheremet, et al.
Published: (2015)

Analysis of a process of peroxidation, caspase-3 and caspase-8 in patients with autoimmune thyroiditis
by: M. I. Sheremet, et al.
Published: (2015)

Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway
by: Ruxue Huang, et al.
Published: (2022)

Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction
by: Liu X, et al.
Published: (2024)

Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury
by: Zhiming Ye, et al.
Published: (2019)

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
by: Raquel Espín, et al.
Published: (2013)

Role of Caspase-3 Level in Perinatal Asphyxia
by: Johnny Rompis, et al.
Published: (2021)

Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis
by: Hongjie Wang, et al.
Published: (2020)

Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis
by: Wang R, et al.
Published: (2021)

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
by: Zhipeng Diao, et al.
Published: (2024)

Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement
by: Liyuan Chen, et al.
Published: (2024)

Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways
by: Wang R, et al.
Published: (2019)

Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance
by: Yumeng Wang, et al.
Published: (2024)

Caspase-3 mediated Apoptosis AT the endometrial hyperplasia in women of reproductive age
by: V. G. Dubinina, et al.
Published: (2016)

Caspase-3 mediated Apoptosis AT the endometrial hyperplasia in women of reproductive age
by: V. G. Dubinina, et al.
Published: (2016)

APOL1 Induces Pyroptosis of Fibroblasts Through NLRP3/Caspase-1/GSDMD Signaling Pathway in Ulcerative Colitis
by: Zhu F, et al.
Published: (2023)

Exploring the total flavones of Abelmoschus manihot against IAV-induced lung inflammation by network pharmacology
by: Yanan Gao, et al.
Published: (2022)

Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves <it>caspase</it>-8 and is defective in <it>caspase</it>-3 deficient mice
by: Flavell Richard A, et al.
Published: (2003)

Calcium Hydroxide Increases Human Umbilical Cord Mesenchymal Stem Cells Expressions of Apoptotic Protease-Activating Factor-1, Caspase-3 and Caspase-9
by: Prasetyo EP, et al.
Published: (2021)

Punicalagin attenuates ventricular remodeling after acute myocardial infarction via regulating the NLRP3/caspase-1 pathway
by: Jian-fei Peng, et al.
Published: (2023)

Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells
by: Zhihui Li, et al.
Published: (2022)

Shen-Ling-Bai-Zhu-San Improves Dextran Sodium Sulfate-Induced Colitis by Inhibiting Caspase-1/Caspase-11-Mediated Pyroptosis
by: Limin Chao, et al.
Published: (2020)

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut-kidney axis
by: Hongmei Yu, et al.
Published: (2024)

Development of caspase-3-selective activity-based probes for PET imaging of apoptosis
by: Louis Lauwerys, et al.
Published: (2024)

Bitongqing Attenuates CIA Rats by Suppressing Macrophage Pyroptosis and Modulating the NLRP3/Caspase-1/GSDMD Pathway
by: Wu Y, et al.
Published: (2024)

A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression
by: Xueyan Zhang, et al.
Published: (2021)

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling
by: Bu-Hui Liu, et al.
Published: (2021)

Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy
by: Shuo Zheng, et al.
Published: (2023)

β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis
by: Di Zhang, et al.
Published: (2023)

Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection
by: Ni Liang, et al.
Published: (2024)

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells
by: Tonghui Li, et al.
Published: (2022)

Caspase-3-dependent Cell Death in B lymphocyte Caused by Pseudomonas aeruginosa Pyocyanin
by: Heni Susilowati, et al.
Published: (2015)