Kallistatin leads to cognition impairment via downregulating glutamine synthetase

• Main Authors: Yanlan Long (Author), Zhen Zhao (Author), Wanting Xie (Author), Jinhui Shi (Author), Fengyu Yang (Author), Dan Zhu (Author), Ping Jiang (Author), Qilong Tang (Author), Zhou Ti (Author), Bin Jiang (Author), Xia Yang (Author), Guoquan Gao (Author), Weiwei Qi (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive impairment. The mRNA and protein expression of SERPINA4(Kallistatin) are higher in patients with AD. However, whether Kallistatin plays a regul...