Genetic Variant <i>ABCC1</i> rs45511401 Is Associated with Increased Response to Statins in Patients with Familial Hypercholesterolemia

• Main Authors: Carolina Dagli-Hernandez (Author), Jéssica Bassani Borges (Author), Elisangela da Silva Rodrigues Marçal (Author), Renata Caroline Costa de Freitas (Author), Augusto Akira Mori (Author), Rodrigo Marques Gonçalves (Author), Andre Arpad Faludi (Author), Victor Fernandes de Oliveira (Author), Glaucio Monteiro Ferreira (Author), Gisele Medeiros Bastos (Author), Yitian Zhou (Author), Volker M. Lauschke (Author), Alvaro Cerda (Author), Mario Hiroyuki Hirata (Author), Rosario Dominguez Crespo Hirata (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Statins are the first-line treatment for familial hypercholesterolemia (FH), but response is highly variable due to genetic and nongenetic factors. Here, we explored the association between response and genetic variability in 114 Brazilian adult FH patients. Specifically, a panel of 84 genes was ana...