OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts

• Main Authors: Yu Toyoda (Author), Yusuke Kawamura (Author), Akiyoshi Nakayama (Author), Keito Morimoto (Author), Seiko Shimizu (Author), Yuki Tanahashi (Author), Takashi Tamura (Author), Takaaki Kondo (Author), Yasufumi Kato (Author), Kimiyoshi Ichida (Author), Hiroshi Suzuki (Author), Nariyoshi Shinomiya (Author), Yasushi Kobayashi (Author), Tappei Takada (Author), Hirotaka Matsuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout. OAT10 is a urate transporter; however, its physiological role in urate handling remains unclear. We hypothesized that OAT10 could b...