Model‐informed precision dosing of vancomycin for rapid achievement of target area under the concentration‐time curve: A simulation study

• Main Authors: Kazutaka Oda (Author), Tomoyuki Yamada (Author), Kazuaki Matsumoto (Author), Yuki Hanai (Author), Takashi Ueda (Author), Masaru Samura (Author), Akari Shigemi (Author), Hirofumi Jono (Author), Hideyuki Saito (Author), Toshimi Kimura (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this study, we aimed to evaluate limited sampling strategies for achieving the therapeutic ranges of the area under the concentration‐time curve (AUC) of vancomycin on the first and second day (AUC0-24, AUC24-48, respectively) of therapy. A virtual population of 1000 individuals was crea...