In vitro characterization of luseogliflozin, a potent and competitive sodium glucose co-transporter 2 inhibitor: Inhibition kinetics and binding studies

In this study, we evaluated an inhibition model of luseogliflozin on sodium glucose co-transporter 2 (SGLT2). We also analyzed the binding kinetics of the drug to SGLT2 protein using [3H]-luseogliflozin. Luseogliflozin competitively inhibited human SGLT2 (hSGLT2)-mediated glucose uptake with a Ki va...

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Bibliographic Details
Main Authors: Saeko Uchida (Author), Akiko Mitani (Author), Emi Gunji (Author), Teisuke Takahashi (Author), Koji Yamamoto (Author)
Format: Book
Published: Elsevier, 2015-05-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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