Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation

• Principais autores: Qiuwei Peng (Autor), Jian Wang (Autor), Man Han (Autor), Minghong Zhao (Autor), Kesong Li (Autor), Tianming Lu (Autor), Qiuyan Guo (Autor), Quan Jiang (Autor)
• Formato: Livro
• Publicado em: BMC, 2023-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Rheumatoid arthritis (RA) is characterized by bone destruction in the afflicted joints, and during the process of bone destruction, osteoclasts play a crucial role. Tanshinone IIA (Tan IIA) has shown anti-inflammatory effects in RA. However, the exact molecular mechanisms by which it delays...