Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

• Ngā kaituhi matua: Lukas Kovar (Author), Christina Schräpel (Author), Dominik Selzer (Author), Yvonne Kohl (Author), Robert Bals (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2020-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially ch...