Cathepsin B deteriorates diabetic cardiomyopathy induced by streptozotocin via promoting NLRP3-mediated pyroptosis

• Main Authors: Chen Liu (Author), Qi Yao (Author), Tongtong Hu (Author), Zhulan Cai (Author), Qingwen Xie (Author), Jinhua Zhao (Author), Yuan Yuan (Author), Jian Ni (Author), Qing Qing Wu (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice heart during pressure overload, while the role of CTSB on diabetic cardiomyopathy has not been fully elucidated. The aim of thi...