LXR deficiency confers increased protection against visceral Leishmania infection in mice.

• Main Authors: Kevin W Bruhn (Author), Chaitra Marathe (Author), Ana Cláudia Maretti-Mira (Author), Hong Nguyen (Author), Jacquelyn Haskell (Author), Thu Anh Tran (Author), Veena Vanchinathan (Author), Upasna Gaur (Author), Mary E Wilson (Author), Peter Tontonoz (Author), Noah Craft (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The liver X receptors (LXRs) are a family of nuclear receptor transcription factors that are activated by oxysterols and have defined roles in both lipid metabolism and cholesterol regulation. LXRs also affect antimicrobial responses and have anti-inflammatory effects in macrophages. As mice lacking...