Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats

• Main Authors: Agnieszka Karbownik (Author), Danuta Szkutnik-Fiedler (Author), Tomasz Grabowski (Author), Anna Wolc (Author), Joanna Stanisławiak-Rudowicz (Author), Radosław Jaźwiec (Author), Edmund Grześkowiak (Author), Edyta Szałek (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A combination of the tyrosine kinase inhibitor-sorafenib-and the opioid analgesic-morphine-can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and...