Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu

• Prif Awduron: Zi-Ru Dai (Awdur), Jing Ning (Awdur), Gui-Bo Sun (Awdur), Ping Wang (Awdur), Feng Zhang (Awdur), Hong-Ying Ma (Awdur), Li-Wei Zou (Awdur), Jie Hou (Awdur), Jing-Jing Wu (Awdur), Guang-Bo Ge (Awdur), Xiao-Bo Sun (Awdur), Ling Yang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Bufotalin (BFT), one of the naturally occurring bufodienolides, has multiple pharmacological and toxicological effects including antitumor activity and cardiotoxicity. This study aimed to character the metabolic pathway(s) of BFT and to identify the key drug metabolizing enzyme(s) responsible for he...