New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer

• Asıl Yazarlar: Haytham O. Tawfik (Yazar), Anwar A. El-Hamaky (Yazar), Eman A. El-Bastawissy (Yazar), Kirill A. Shcherbakov (Yazar), Alexander V. Veselovsky (Yazar), Yulia A. Gladilina (Yazar), Dmitry D. Zhdanov (Yazar), Mervat H. El-Hamamsy (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere length and chromosomal integrity of frequently dividing cells. Although it is silenced in most human somatic cells,...