Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy

• Main Authors: José A. Fernández-Albarral (Author), Elena Salobrar-García (Author), José A. Matamoros (Author), Cristina Fernández-Mendívil (Author), Eric del Sastre (Author), Lejing Chen (Author), Rosa de Hoz (Author), Inés López-Cuenca (Author), Lidia Sánchez-Puebla (Author), José M. Ramírez (Author), Juan J. Salazar (Author), Manuela G. Lopez (Author), Ana I. Ramírez (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tauopathies such as Alzheimer's disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer's patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia, causing iron accumulation, neuroinf...