SS31 Ameliorates Podocyte Injury via Inhibiting OMA1-Mediated Hydrolysis of OPA1 in Diabetic Kidney Disease

• Main Authors: Qianqian Yang (Author), Wenjia Xie (Author), Xiao Wang (Author), Jing Luo (Author), Yang Zhou (Author), Hongdi Cao (Author), Qi Sun (Author), Lei Jiang (Author), Junwei Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic kidney disease (DKD) is currently one of the leading causes of end-stage renal disease (ESRD). Mitochondrial dysfunction in podocyte is involve in DKD development. However, whether early mitochondrial stabilization delays or reverses DKD progression has not been elucidated. SS31 is a novel...