Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

• Main Authors: Nuria Vilaboa (Author), Juan Antonio Lopez (Author), Marco de Mesa (Author), Clara Escudero-Duch (Author), Natalie Winfield (Author), Melanie Bayford (Author), Richard Voellmy (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions...