Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

• 主要な著者: Jing Ling (著者), Xuping Yang (著者), Lulu Dong (著者), Yan Jiang (著者), Sulan Zou (著者), Nan Hu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Voriconazole is a broad-spectrum triazole antifungal agent. A number of studies have revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was associated with the CYP2C19 phenotype. However, the combined effects of CYP2C19 genetic polymorphisms and inflammation on vor...