A living cell-based fluorescent reporter for high-throughput screening of anti-tumor drugs

• Main Authors: Ningning Tang (Author), Ling Li (Author), Fei Xie (Author), Ying Lu (Author), Zifan Zuo (Author), Hao Shan (Author), Quan Zhang (Author), Lianwen Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Suppression of cellular O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) can repress proliferation and migration of various cancer cells, which opens a new avenue for cancer therapy. Based on the regulation of insulin gene transcription, we designed a cell-based fluorescent reporter capable of...