A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice.

• Main Authors: Grace K Tan (Author), Jowin K W Ng (Author), Scott L Trasti (Author), Wouter Schul (Author), George Yip (Author), Sylvie Alonso (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the la...