ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

• Main Authors: Xun Chi (Author), Emily C. Britt (Author), Hannah W. Shows (Author), Alexander J. Hjelmaas (Author), Shwetha K. Shetty (Author), Emily M. Cushing (Author), Wendy Li (Author), Alex Dou (Author), Ren Zhang (Author), Brandon S.J. Davies (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity. Deficiency in either ANGPTL3 or ANGPTL8 reduces plasma triglyceride levels and increases LPL activity, whereas overexpression of either protein...