Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins

• Main Authors: J.J. Hulmi (Author), F. Penna (Author), N. Pöllänen (Author), T.A. Nissinen (Author), J. Hentilä (Author), L. Euro (Author), J.H. Lautaoja (Author), R. Ballarò (Author), R. Soliymani (Author), M. Baumann (Author), O. Ritvos (Author), E. Pirinen (Author), M. Lalowski (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an effect on tumour growth. However, the underlying m...