Discovery of SIPI6473, a New, Potent, and Orally Bioavailable Multikinase Inhibitor for the Treatment of Non-small Cell Lung Cancer

• Main Authors: Xiu Gu (Author), Zi-Xue Zhang (Author), Min-Ru Jiao (Author), Xin-Yan Peng (Author), Jian-Qi Li (Author), Qing-Wei Zhang (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the estimated glomerular filtration rate (E...