Discovery of SIPI6473, a New, Potent, and Orally Bioavailable Multikinase Inhibitor for the Treatment of Non-small Cell Lung Cancer

• Автори: Xiu Gu (Автор), Zi-Xue Zhang (Автор), Min-Ru Jiao (Автор), Xin-Yan Peng (Автор), Jian-Qi Li (Автор), Qing-Wei Zhang (Автор)
• Формат: Книга
• Опубліковано: Georg Thieme Verlag KG, 2021-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the estimated glomerular filtration rate (E...