Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos

• Main Authors: You-Jiao Wu (Author), Zhan-Hua Li (Author), Jiu-Yan Li (Author), Yan Zhou (Author), Run-Yue Wang (Author), Xiao-Yi Chen (Author), Lin-Sen Qing (Author), Pei Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LS-102 is a new derivative of astragaloside IV (AGS IV) that has been shown to possess potentially significant cardioprotective effects. However, there are no reports concerning its interaction with human serum albumin (HSA) and toxicology in vertebrates. The present investigation was undertaken to...