A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy

• Main Authors: Jin Wang (Author), Bertrand Z. Yeung (Author), M. Guillaume Wientjes (Author), Minjian Cui (Author), Cody J. Peer (Author), Ze Lu (Author), William D. Figg (Author), Sukyung Woo (Author), Jessie L.-S. Au (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug efflux and the effects of exosome inhibition. The experiment...