Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis

• Main Authors: Andrea S. Pereyra (Author), Regina F. Fernandez (Author), Adam Amorese (Author), Jasmine N. Castro (Author), Chien-Te Lin (Author), Espen E. Spangenburg (Author), Jessica M. Ellis (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Abnormal lipid metabolism in mammalian tissues can be highly deleterious, leading to organ failure. Carnitine Palmitoyltransferase 2 (CPT2) deficiency is an inherited metabolic disorder affecting the liver, heart, and skeletal muscle due to impaired mitochondrial oxidation of long-chain f...