Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis

• Hauptverfasser: Andrea S. Pereyra (Verfasst von), Regina F. Fernandez (Verfasst von), Adam Amorese (Verfasst von), Jasmine N. Castro (Verfasst von), Chien-Te Lin (Verfasst von), Espen E. Spangenburg (Verfasst von), Jessica M. Ellis (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2024-11-01T00:00:00Z.
• Schlagworte: article
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Objective: Abnormal lipid metabolism in mammalian tissues can be highly deleterious, leading to organ failure. Carnitine Palmitoyltransferase 2 (CPT2) deficiency is an inherited metabolic disorder affecting the liver, heart, and skeletal muscle due to impaired mitochondrial oxidation of long-chain f...