The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer's disease pathology

In the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potential therapeutic applications against Alzheimer'...

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Hoofdauteurs: Vaia-Argyro Bakalakou (Auteur), Barbara Mavroidi (Auteur), Amalia D. Kalampaliki (Auteur), Béatrice Josselin (Auteur), Stéphane Bach (Auteur), Alexios-Leandros Skaltsounis (Auteur), Panagiotis Marakos (Auteur), Nicole Pouli (Auteur), Maria Pelecanou (Auteur), Vassilios Myrianthopoulos (Auteur), Sandrine Ruchaud (Auteur), Ioannis K. Kostakis (Auteur)
Formaat: Boek
Gepubliceerd in: Elsevier, 2024-12-01T00:00:00Z.
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