The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer's disease pathology

• Main Authors: Vaia-Argyro Bakalakou (Author), Barbara Mavroidi (Author), Amalia D. Kalampaliki (Author), Béatrice Josselin (Author), Stéphane Bach (Author), Alexios-Leandros Skaltsounis (Author), Panagiotis Marakos (Author), Nicole Pouli (Author), Maria Pelecanou (Author), Vassilios Myrianthopoulos (Author), Sandrine Ruchaud (Author), Ioannis K. Kostakis (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potential therapeutic applications against Alzheimer'...