Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Abstract Background [18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used radiotracers for imaging hypoxia and tau pathology, respectively. Both...

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Main Authors: Takayuki Ohkubo (Author), Yusuke Kurihara (Author), Masanao Ogawa (Author), Nobuki Nengaki (Author), Masayuki Fujinaga (Author), Wakana Mori (Author), Katsushi Kumata (Author), Masayuki Hanyu (Author), Kenji Furutsuka (Author), Hiroki Hashimoto (Author), Kazunori Kawamura (Author), Ming-Rong Zhang (Author)
Format: Book
Published: SpringerOpen, 2021-07-01T00:00:00Z.
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