Virtual Screening, Molecular Dynamics, and Mechanism Study of Homeodomain-Interacting Protein Kinase 2 Inhibitor in Renal Fibroblasts

• Main Authors: Xinlan Hu (Author), Yan Wu (Author), Hanyi Ouyang (Author), Jiayan Wu (Author), Mengmeng Yao (Author), Zhuo Chen (Author), Qianbin Li (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives:</b> Homeodomain-interacting protein kinase 2 (HIPK2) is critically involved in the progression of renal fibrosis. This study aims to identify and characterize a novel HIPK2 inhibitor, CHR-6494, and investigate its therapeutic potential. <b>Methods:</b&g...