Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

• Main Authors: Xiao-Hong Li (Author), Yu-Xin Xu (Author), Gill Vance (Author), Yun Wang (Author), Long-Bao Lv (Author), Govert J van Dam (Author), Jian-Ping Cao (Author), R Alan Wilson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Rhesus macaques are unusual among schistosome hosts, self-curing from an established infection and thereafter manifesting solid immunity against a challenge, an ideal model for vaccine development. Previously, the immunological basis of self-cure was confirmed; surviving worms had ceased...