Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?

• मुख्य लेखकों: Ema Valentina Brovč (लेखक), Stane Pajk (लेखक), Roman Šink (लेखक), Janez Mravljak (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts of Fe(...