Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

• Main Authors: Paul R. Stabach (Author), Kristin Zimmerman (Author), Aaron Adame (Author), Dillon Kavanagh (Author), Christopher T. Saeui (Author), Christian Agatemor (Author), Shawn Gray (Author), Wenxiang Cao (Author), Enrique M. De La Cruz (Author), Kevin J. Yarema (Author), Demetrios T. Braddock (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase‐1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glycan optimization, and a novel biomanufacturing platform to enha...