9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation

• Egile Nagusiak: Mikhail V. Khvostov (Egilea), Elizaveta D. Gladkova (Egilea), Sergey A. Borisov (Egilea), Marina S. Fedotova (Egilea), Nataliya A. Zhukova (Egilea), Mariya K. Marenina (Egilea), Yulia V. Meshkova (Egilea), Nicolae Valutsa (Egilea), Olga A. Luzina (Egilea), Tatiana G. Tolstikova (Egilea), Nariman F. Salakhutdinov (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimul...