IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.

• Asıl Yazarlar: Mathilde Guerbois (Yazar), Eugenia Volkova (Yazar), Naomi L Forrester (Yazar), Shannan L Rossi (Yazar), Ilya Frolov (Yazar), Scott C Weaver (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The live-attenuated TC-83 strain is the only licensed veterinary vaccine available to protect equids against Venezuelan equine encephalitis virus (VEEV) and to protect humans indirectly by preventing equine amplification. However, TC-83 is reactogenic due to its reliance on only two attenuating poin...